Understanding Viral Transmission Behavior via Protein Intrinsic Disorder Prediction: Coronaviruses
Identifieur interne : 001C27 ( Main/Exploration ); précédent : 001C26; suivant : 001C28Understanding Viral Transmission Behavior via Protein Intrinsic Disorder Prediction: Coronaviruses
Auteurs : Gerard Kian-Meng Goh [États-Unis, Singapour] ; A. Keith Dunker [États-Unis] ; Vladimir N. Uversky [États-Unis, Russie]Source :
- Journal of Pathogens [ 2090-3057 ] ; 2012.
Abstract
Besides being a common threat to farm animals and poultry, coronavirus (CoV) was responsible for the human severe acute respiratory syndrome (SARS) epidemic in 2002–4. However, many aspects of CoV behavior, including modes of its transmission, are yet to be fully understood. We show that the amount and the peculiarities of distribution of the protein intrinsic disorder in the viral shell can be used for the efficient analysis of the behavior and transmission modes of CoV. The proposed model allows categorization of the various CoVs by the peculiarities of disorder distribution in their membrane (M) and nucleocapsid (N). This categorization enables quick identification of viruses with similar behaviors in transmission, regardless of genetic proximity. Based on this analysis, an empirical model for predicting the viral transmission behavior is developed. This model is able to explain some behavioral aspects of important coronaviruses that previously were not fully understood. The new predictor can be a useful tool for better epidemiological, clinical, and structural understanding of behavior of both newly emerging viruses and viruses that have been known for a long time. A potentially new vaccine strategy could involve searches for viral strains that are characterized by the evolutionary misfit between the peculiarities of the disorder distribution in their shells and their behavior.
Url:
DOI: 10.1155/2012/738590
PubMed: 23097708
PubMed Central: 3477565
Affiliations:
- Russie, Singapour, États-Unis
- Floride, Indiana
- Tampa
- Université de Floride du Sud, Université nationale de Singapour
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Keith" last="Dunker">A. Keith Dunker</name><affiliation wicri:level="2"><nlm:aff id="I1">Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN 46202, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN 46202</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Uversky, Vladimir N" sort="Uversky, Vladimir N" uniqKey="Uversky V" first="Vladimir N." last="Uversky">Vladimir N. Uversky</name><affiliation wicri:level="4"><nlm:aff id="I3">Department of Molecular Medicine, University of South Florida, Tampa, FL 33612, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Medicine, University of South Florida, Tampa, FL 33612</wicri:regionArea><placeName><region type="state">Floride</region><settlement type="city">Tampa</settlement></placeName><orgName type="university">Université de Floride du Sud</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="I4">Institute for Biological Instrumentation, Russian Academy of Sciences, 142290 Pushchino, Russia</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>Institute for Biological Instrumentation, Russian Academy of Sciences, 142290 Pushchino</wicri:regionArea><wicri:noRegion>142290 Pushchino</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of Pathogens</title><idno type="ISSN">2090-3057</idno><idno type="eISSN">2090-3065</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Besides being a common threat to farm animals and poultry, coronavirus (CoV) was responsible for the human severe acute respiratory syndrome (SARS) epidemic in 2002–4. However, many aspects of CoV behavior, including modes of its transmission, are yet to be fully understood. We show that the amount and the peculiarities of distribution of the protein intrinsic disorder in the viral shell can be used for the efficient analysis of the behavior and transmission modes of CoV. The proposed model allows categorization of the various CoVs by the peculiarities of disorder distribution in their membrane (M) and nucleocapsid (N). This categorization enables quick identification of viruses with similar behaviors in transmission, regardless of genetic proximity. Based on this analysis, an empirical model for predicting the viral transmission behavior is developed. This model is able to explain some behavioral aspects of important coronaviruses that previously were not fully understood. The new predictor can be a useful tool for better epidemiological, clinical, and structural understanding of behavior of both newly emerging viruses and viruses that have been known for a long time. A potentially new vaccine strategy could involve searches for viral strains that are characterized by the evolutionary misfit between the peculiarities of the disorder distribution in their shells and their behavior.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Goh, Gkm" uniqKey="Goh G">GKM Goh</name></author><author><name sortKey="Uversky, Vn" uniqKey="Uversky V">VN Uversky</name></author><author><name sortKey="Dunker, Ak" uniqKey="Dunker A">AK Dunker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goh, Gkm" uniqKey="Goh G">GKM Goh</name></author><author><name sortKey="Dunker, Ak" uniqKey="Dunker A">AK Dunker</name></author><author><name sortKey="Uversky, Vn" uniqKey="Uversky V">VN Uversky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xue, B" uniqKey="Xue B">B Xue</name></author><author><name sortKey="Williams, Rw" uniqKey="Williams R">RW 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Wu</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Russie</li><li>Singapour</li><li>États-Unis</li></country><region><li>Floride</li><li>Indiana</li></region><settlement><li>Tampa</li></settlement><orgName><li>Université de Floride du Sud</li><li>Université nationale de Singapour</li></orgName></list><tree><country name="États-Unis"><region name="Indiana"><name sortKey="Goh, Gerard Kian Meng" sort="Goh, Gerard Kian Meng" uniqKey="Goh G" first="Gerard Kian-Meng" last="Goh">Gerard Kian-Meng Goh</name></region><name sortKey="Dunker, A Keith" sort="Dunker, A Keith" uniqKey="Dunker A" first="A. Keith" last="Dunker">A. Keith Dunker</name><name sortKey="Uversky, Vladimir N" sort="Uversky, Vladimir N" uniqKey="Uversky V" first="Vladimir N." last="Uversky">Vladimir N. Uversky</name></country><country name="Singapour"><noRegion><name sortKey="Goh, Gerard Kian Meng" sort="Goh, Gerard Kian Meng" uniqKey="Goh G" first="Gerard Kian-Meng" last="Goh">Gerard Kian-Meng Goh</name></noRegion></country><country name="Russie"><noRegion><name sortKey="Uversky, Vladimir N" sort="Uversky, Vladimir N" uniqKey="Uversky V" first="Vladimir N." last="Uversky">Vladimir N. Uversky</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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